Do Women Truly Have Less Than Optimal Outcome Post-Heart Transplantation Compared to Men

PurposeIt has been reported from the ISHLT registry that women have less optimal outcome after heart transplantation (HTx) compared to men. It is not known whether this difference due rejection, NF-MACE, or decreased survival.MethodsBetween 2010 and 2020, we assessed 1071 HTx patients divided them by male female sex. 309 females 762 males were included in study. Post-transplant outcomes 1-year survival, freedom cardiac allograft vasculopathy (CAV, stenosis ≥30% angiography), non-fatal major adverse events (NF-MACE: myocardial infarction, new congestive failure, percutaneous coronary intervention, implantable cardioverter defibrillator/pacemaker implant, stroke), rejection (acute cellular [ACR], antibody-mediated [AMR]), de novo DSA production. Women into two groups, sensitized (PRA >10%) non-sensitized.ResultsWhen comparing men, had similar CAV, but significantly lower ATR, AMR, who survival production non-sensitized women. 26% of our sensitized.ConclusionMajor post-transplant are for However, sensitization may be reason more AMR it does affect short-term outcomes. Longer follow-up impact these need assessed. survival. Between non-sensitized. When sensitized. Major